In this paper, a new experiment procedure is proposed to study the influence of cutter parameters and clamping methods on the stability of the milling process of thin-walled blade. A dedicated fixture is designed to carry out the experiment. Simulation results show that the new clamping system can enhance the rigidity of thin-walled blade to reduce cutting deformation and chatter vibration phenomenon. Then, cutter and cutting parameters can be optimized properly to make the system obtain high rigidity and high performance stable milling process. Industrial application indicates that the new system can improve the cutting performance and ensure the cutting quality.