Paper Title:
Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector
  Abstract

Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positive surface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. The pDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited and efficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viral gene vectors for gene therapy.

  Info
Periodical
Advanced Materials Research (Volumes 47-50)
Edited by
Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam
Pages
1319-1322
DOI
10.4028/www.scientific.net/AMR.47-50.1319
Citation
Y. Zhao, P. Yin, Z. Y. Wang, L. Ren, Q. Q. Zhang, "Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector", Advanced Materials Research, Vols. 47-50, pp. 1319-1322, 2008
Online since
June 2008
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$32.00
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