Paper Title:
Biocompatibility and Osteogenesis of Calcium Phosphate Cement Scaffolds for Bone Tissue Engineering
  Abstract

Porous calcium phosphate cement (CPC) scaffolds were successfully fabricated utilizing particle-leaching method. Mesenchymal stem cells (MSCs) were cultured, expanded and seeded on the scaffolds and the proliferation and differentiation of MSCs into osteoblastic phenotype were determined using MTT assay, ALP activity and ESEM. The results revealed that the CPC scaffolds were biocompatible and had no negative effects on the MSCs in vitro. The in vivo biocompatibility and osteogenicity of the scaffolds were investigated. Both pure scaffolds and MSCs/scaffold constructs were implanted in rabbit mandibles and studied histologically. The results showed that CPC scaffolds exhibited good biocompatibility and osteoconductivity. Moreover, the introduction of MSCs into the scaffolds dramatically enhanced the efficiency of new bone formation initially.

  Info
Periodical
Advanced Materials Research (Volumes 47-50)
Edited by
Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam
Pages
1383-1386
DOI
10.4028/www.scientific.net/AMR.47-50.1383
Citation
H. Guo, J. Wei, H. Kong, C. S. Liu, K. F. Pan, "Biocompatibility and Osteogenesis of Calcium Phosphate Cement Scaffolds for Bone Tissue Engineering", Advanced Materials Research, Vols. 47-50, pp. 1383-1386, Jun. 2008
Online since
June 2008
Price
US$ 28,-
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