Expanded polytetrafluoroethylene (ePTFE) is a bioinert material. It has the superior properties of thermal and chemical stabilities, low surface energy and high resistivity, so it was applied in many biomedical fields. In order to improve the ePTFE film biocompatibility, the cold plasma technology was used with acetic acid as monomer to deposit onto ePTFE film and then (N-isopropylacrylamide) was grafted onto the surface by photo-grafting. The characteristics of the material surface were evaluated with X-ray photoelectron spectroscopy (XPS), FTIR and water contact angle. It was found that the contact angle of water on the untreated ePTFE significantly decrease from125° to 72° after ePTFE film being treated with acetic acid plasma deposition procedure. Due to the hydrophilicity of poly(N-isopropylacrylamide), so the contact angle of water on the ePTFE-g-NIPAAm almost approached to 0°. And we obtained the thermal-sensitive ePTFE hydrogels.