Paper Title:

Proteoglycan Analogues for Ophthalmic and Orthopaedic Applications

Periodical Advanced Materials Research (Volume 506)
Main Theme Biomaterials and Applications
Edited by Tawee Tunkasiri
Pages 3-6
DOI 10.4028/www.scientific.net/AMR.506.3
Citation B.J. Tighe et al., 2012, Advanced Materials Research, 506, 3
Online since April, 2012
Authors B.J. Tighe, J. Bramhill, D.C. Campbell
Keywords Elastic Modulus, Hydrogel, Sulphonates
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Abstract

The successful development of biomaterials is increasingly influenced by biomimesis essentially the use of biological structures as design templates. This approach has been used here in the design of injectable systems for the nucleus of the intervertebral disc, corneal inlays and intraocular lenses (IOLs). The strategy is based on the use of C-linked sulphonates to mimic the O-linked sulphate groups that are the hydration drivers in proteoglycans. The elastic modulus of the materials can be tailored for specific applications.