Preparation of Cortex Moutan Nanoparticles and its Microscopic Characteristics and Physicochemical Properties

Li, Peng; Cui, Yu Jia; Wang, Wei Guo; Zhao, Yong Liang; Gu, Ya Nan; Meng, Tian Tian; Ding, Jin Ju; Zhang, Peng; Jia, Ke

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Home > Advanced Materials Research > Frontier of Nanoscience and Technology II > Preparation of Cortex Moutan Nanoparticles and its...

Paper Title:

Preparation of Cortex Moutan Nanoparticles and its Microscopic Characteristics and Physicochemical Properties

Periodical	Advanced Materials Research (Volume 528)
Main Theme	Frontier of Nanoscience and Technology II
Edited by	Jimmy (C.M.) Kao, Meng Hou and Ran Chen
Pages	54-57
DOI	10.4028/www.scientific.net/AMR.528.54
Citation	Yu Jia Cui et al., 2012, Advanced Materials Research, 528, 54
Online since	June, 2012
Authors	Yu Jia Cui, Wei Guo Wang, Peng Li, Yong Liang Zhao, Ya Nan Gu, Tian Tian Meng, Jin Ju Ding, Peng Zhang, Ke Jia
Keywords	Cortex Moutan, Dissolution, Fluidity, Paeonol, Stability, Super-Micro-Particle Pulverization
Price	US$ 28,-

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Abstract

Objective In order to increase the Paeonol dissolution and content, cortex moutan were smashed into nanoparticles, and the dissolution and content were compared by microscopy before and after super-micro-particle pulverization. Methods Super-micro-particle pulverization and general grinding were used to broke Cortex moutan into particles. The microscopic morphous characteristics of the before- and after- ultra-disintegration particles were compared by microscopy. Methods of HPLC was used to determine the content and dissolution of Paeonol with different grinding conditions. Methods of precipitation and funnel way were used to examine the stability and fluidity of cortex moutan nano-particles. Results Cortex moutan powder after super-micro-particle pulverization appears sphere or like-sphere, and its average size is 200nm~300nm. After the superfine grinding Paeonol dissolution increases 76.19% in comparison with without nano pulverization. The nanoparticle rest angle is θ=33°.The precipitation ratio of Cortex moutan powder with general grinding is 0.28 at 24h, and the precipitation ratio of its nano-power has been to 0.98 at 60min. Conclusion Paeonol dissolution, stability and fluidity of Cortex moutan nanoparticles were improved greatly and this nanoparticles is beneficial to industrial production for traditional Chinese medicine.