Ultrastructural Characterization of Liposomes
Using Transmission Electron Microscope
|
| Journal |
Advanced Materials Research (Volumes 55 - 57) |
| Volume |
Smart Materials |
| Edited by |
Tawee Tunkasiri |
| Pages |
709-711 |
| DOI |
10.4028/www.scientific.net/AMR.55-57.709 |
| Online since |
August, 2008 |
| Authors |
Prukswan Chetanachan, P. Akarachalanon, D. Worawirunwong, Pisutti Dararutana, A. Bangtrakulnonth, M. Bunjop, S. Kongmuang |
| Keywords |
Liposome, Negative Staining, Thin Film Method, Transmission Electron Microscopy (TEM) |
| Abstract |
A liposome is a spherical vesicle composed of phospholipids and cholesterol bilayer membrane and contains a core of aqueous solution. Liposomes are polymeric nanoparticles used for drug delivery due to their unique properties. It can carry both hydrophobic and hydrophilic molecules. In this study, we showed the benefit of using transmission electron microscope (TEM) with negative staining technique to investigate the morphology of liposomes produced by thin film method. At the same magnification of micrograph results, we could see the multilamellar vesicles of liposomes in various figures and different sizes. |
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