Paper Title:
Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro
  Abstract

Proliferation and migration of vascular smooth muscle cells(VSMCs) into the sub-intimal space play an important role in intimal thickening in atherosclerosis and in-stent restenosis. Arsenic compounds are natural substances that have been used in the treatment of patients with acute promyelocytic leukemia (APL).And Arsenic trioxide (As2O3) is known to be a potent inhibitor of cell proliferation.The aim of this study was to prepare arsenic trioxide (As2O3) -loaded PLGA nanoparticles(As2O3-PLGA-NP) and investigate its general properties, preservation of As2O3 bioactivity and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(RVSMCs) in vitro. With PLGA as carrier,As2O3 drug delivery nanoparticles were prepared by w /o /w double-emulsion evaporation technique,and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(VSMCs) in vitro was investigated.The results of the experiment show the self-prepared As2O3-PLGA-NP were approximately spherical,with the mean diameter of 90±25.03 nm, and the average drug loading was 1.72% .The As2O3-PLGA-NP has drug sustained-release character and can prolong the phase of the inhibitory effect of As2O3 against RVSMCs.The As2O3-PLGA-NP do not reduce the biological activity of As2O3.

  Info
Periodical
Advanced Materials Research (Volumes 60-61)
Edited by
Xiaohao Wang
Pages
125-129
DOI
10.4028/www.scientific.net/AMR.60-61.125
Citation
S. S. Zhao, Q. Lu, D. S. Zhang, "Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro", Advanced Materials Research, Vols. 60-61, pp. 125-129, 2009
Online since
January 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Bao Zhang, Jia Feng Zhang
Chapter 3: Chemical Separation Engineering
Abstract:Arsenic contamination of water and associated health risks have been reported in many regions of China. Leaching of arsenic from industrial...
631
Authors: Ming Yu Li, Hai Bo Wu, Pei Pei Ma, Gang Cao, Lin Song, Gang Ren
Chapter 3: Prevention of Water Environment Pollution
Abstract:The removal of arsenic in micro-polluted water by enhanced coagulation with Poly Ferric Metasilicate (PFSS) was studied. The effects of...
594
Authors: Xin Ke, Ying Sun, Yun Zhang
Chapter 3: Environmental Science, Analysis and Engineering
Abstract:Toxicity of As on soil neutral phosphatase was studied through a series indoor incubation experiments. Results showed that the activity of...
1195
Authors: Meng Nan Lu, Aleksandar N. Nikoloski, Pritam Singh, Dale Parsonage, Radhanath Prasad Das, Li Bo Zhang, Wei Li, Jin Hui Peng
Chapter 2: Analytical and Environmental Chemistry, Waste Disposal and Utilization Technology
Abstract:A novel method for preparation of iron oxyhydroxide materials, involving aqueous precipitation followed by microwave assisted aging is...
249
Authors: Lin Zhuan Ma, Jun Ming Guo, Qiong Fang Cui, Man Hong Liu, Ying Jie Zhang
Chapter 2: Material Science, Materials Processing and Manufacturing Processes Technology
Abstract:The technology of the acidification is adopted to prepare arsenic trioxide (As2O3). With a concentration of 98% of concentrated sulfuric acid...
437