A novel control strategy for on-line polishing wheel wearing compensation in a polyhedral glass grinding machine is proposed, which is mainly consisted of hybrid feed-forward feed-backward control scheme and adaptive wearing prediction algorithm. It has advantage of eliminating the size excursion of polishing roller during long term operation, while the implementation of high accuracy diameter measurement is unnecessary. Hence it greatly reduces the demand for precise sensor and complicated calculation algorithm. Consequently, surface polishing quality and flexibility of the grinding machine was enhanced greatly. Theoretical analysis and experiment result obtained from a laboratory prototype shows good agreement, which indicates that the proposed control strategy has good performance in polishing wheel diameter compensation applications.