High Speed Machining (HSM) has been proved to be useful in the machining of many materials. This research is concerned with the performance of HSM in the milling of Ti-6.5Al-2Zr-1Mo-1V (TA15) titanium alloy. The tool life and wear mechanism of the milling tool under different cutting speed were investigated, and the influences of cutting speed on the surface integrity and fatigue property of the machined part were studied. According to the experimental results, acceptable tool life can be obtained in a speed range up to 200m/min. The results also show that increasing cutting speed can help to improve the surface integrity and fatigue property of the machined part.