Paper Title:
Characteristics of Biodegradable Implantable Drug Delivery System with Micro-Porous Structure
  Abstract

To eliminate the release-delayed phenomenon of macromolecular drug delivery system at the early stage, biodegradable implantable drug delivery system with micro-porous structure was designed by Bio-MEMS technology in this paper. Water absorption and degradation characters of polylactic acid - polyglycolic acid (PLGA) material with different monomer ratio were studied. Drug release model was built by mass transfer equation and the Finite Element Method. Influencing factors about the cumulative amount of release drug were analyzed. And the results suggest that with more ratio of polylactic acid(PLA), PLGA would have more greater amount of water absorbed as well as a longer degradation time. Better linearity of cumulative amount of release drug would be achieved by reducing the diameter and number of micro-porous.

  Info
Periodical
Edited by
Selin Teo, A. Q. Liu, H. Li and B. Tarik
Pages
307-310
DOI
10.4028/www.scientific.net/AMR.74.307
Citation
Y. Gao, X. P. Wang, T. N. Chen, "Characteristics of Biodegradable Implantable Drug Delivery System with Micro-Porous Structure", Advanced Materials Research, Vol. 74, pp. 307-310, 2009
Online since
June 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Yong Chun Huang, Chao Yue Zhao, Feng Yang, Ren He
Mechanical Dynamics and Its Applications
Abstract:The electrochemical degradation of chitosan was studied with using graphite as anode and cathode, NaCl solution as supporting electrolyte....
1899
Authors: Bo Wu, Chang Lu Wang, Ya Qiong Liu, Dong He, Mian Hua Chen, Yu Rong Wang, Feng Juan Li
Chapter 4: Biomaterials Science and Environmental Engineering
Abstract:. A castor oil-based detection method for the analysis of biological degradation was established on the base of CEC-L-33-A-93 test method and...
1182
Authors: Akhtar Jahan Siddiqa, Koel Chaudhury, Basudam Adhikari
Chapter 4: Nanomaterials - Synthesis and Application
Abstract:The present work focuses on the development of biodegradable PLGA nanoparticles (NPs) for controlled release of a breast cancer drug,...
312
Authors: S. Nagalakshmi, T. Sandeep, S. Shanmuganathan
Abstract:Delivery of drug through topical route, delivers most convenient and novel approach. The Skin can offer several advantages as a route of drug...
1