Numerical simulation of dense-phase pneumatic conveying flow field was carried out by using k-ε-ks-εs two-fluid model in horizontal pipe on the basis of kinetic theory of granular flow. The coupling issue between gas phase and solid phase was taken into account in the process of simulation. Such characteristics of flow field along pipe as pressure distribution, concentration distribution, gas and particle velocity distribution were obtained. The results of numerical simulation showed the tends of pressure, gas velocity, particle concentration in pipeline. The results of numerical simulation were compared with experimental results, and it showed that the simulation results were validated by the experimental data, which indicate that the model and the corresponding algorithm have higher accuracy and better prediction. Thus the numerical simulation method can reveal the basic characteristics of dense phase pneumatic conveying in horizontal pipe.