The work aims to investigate the anti-corrosion behavior of silane treated LY12 aluminum alloy (AA LY12) and optimize the process conditions of silane treatment. The silane films were prepared on AA LY12 from γ-aminopropyltriethoxysilane (γ-APS) hydrolized in ethanol/water mixture by dip coating method. The optimum process parameters were obtained from the orthogonal designs in terms of silane solution concentration, ethanol/water ratio, dipping time, curing temperature and curing time. Prior and after silane treatment, the surface of AA LY12 was characterized by contact angle measurements and scan electron microscopy (SEM). The potentiodynamic polarization tests and electrochemical impedance spectroscopy measurements (EIS) were employed to study the anti-corrosion characteristics of silane films on AA LY12. The impedance plots were fitted with the different equivalent circuits. Furthermore, the influence of the above process parameters of silane treatment on film formation and anti-corrosion performance was explored. The results indicate that the γ-APS treated AA LY12 significantly improved the corrosion resistance, compared to the untreated one.