Paper Title:
Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing
  Abstract

AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database., All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.

  Info
Periodical
Advanced Materials Research (Volumes 79-82)
Edited by
Yansheng Yin and Xin Wang
Pages
2187-2190
DOI
10.4028/www.scientific.net/AMR.79-82.2187
Citation
Y. H. Chang, T. Y. Ho, C. H. Wu, C. Y. Chen, H. J. Huang, F. J. Tsai, C. H. Tsai, C. Y. C. Chen, "Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing", Advanced Materials Research, Vols. 79-82, pp. 2187-2190, 2009
Online since
August 2009
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$32.00
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