Paper Title:
In Vivo Biocompatibility Studies of Nano TiO2 Materials
  Abstract

TiO2 nanomaterials with different dimensions(zero and one), sizes(20nm, 50nm and 100nm in diameter) and crystal structures(100% rutile, 100% anatase and combination of 20% rutile and 80% anatase) were confected to suspensions and ointment with varied concentrations and evaluated in animal model (Balb-c mouse). These mouse were divided into various groups randomly, with suspension intraperitoneally injected or ointment transdermally daubed. Heart, lung, liver and kidney were collected and prepared to HE sample after one week. Spectrophotometry was applied to study total antioxide capability and catalase activity of blood and tissues. It has been shown that all TiO2 nanomaterial groups had no effect on lives’ morphology and oxidative stress, with no obvious histopathological changes observed in heart, lung, liver and kidney, and these tissues presented no vacuolar degeneration, necrosis edema, engorgement and inflammation.

  Info
Periodical
Advanced Materials Research (Volumes 79-82)
Edited by
Yansheng Yin and Xin Wang
Pages
389-392
DOI
10.4028/www.scientific.net/AMR.79-82.389
Citation
W. Han, Y. D. Wang, Y. F. Zheng, "In Vivo Biocompatibility Studies of Nano TiO2 Materials", Advanced Materials Research, Vols. 79-82, pp. 389-392, 2009
Online since
August 2009
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Price
$32.00
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