The run-of-mine of complex lead-zinc ores in Yunnan contains 3.26% lead and 2.54% zinc. When traditional selective flotation flowsheet was adopted, 3.77% yield and 61.92% grade of lead concentrate as well as 5.65% yield and 38.67% grade of zinc concentrate were achieved. Simultaneously, 72.39％ lead recovery and 3.83% zinc grade in lead concentrate as well as 80.64% zinc recovery and 6.39% lead grade in zinc concentrate were obtained. Lead concentrate and zinc concentrate obtained from selective flotation contain each other severely, resulting in low recovery of lead and zinc and severe loss of metal, which influences subsequent smelting flowsheet. In addition, due to requirement of large amount of depressant and activator while separating lead and zinc in the process of mineral processing, the cost is very high and the compositions of tail water which can not be recycled by the plant are very complicated. For the combined flowsheet of beneficiation and metallurgy, bulk flotation flowsheet was adopted. Therefore, 11.22% yield of combined lead and zinc concentrate with 25.55% lead grade, 18.33% zinc grade and 86.36% lead recovery were obtained. Gravity separation technology was utilized to separate combined concentrate of lead and zinc. After selecting out part of high quality lead concentrate, the remaining combined concentrate of lead and zinc was treated by acid leaching under high pressure. The final leaching efficiency of zinc was able to reach 97%. The new combined flowsheet has lots of advantages such as shorter flowsheet of beneficiation, simpler reagents, more direct reuse of backwater and higher recovery of metals.