Paper Title:
Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications
  Abstract

New hybrid macroporous scaffolds of polycaprolactone (PCL)/tricalcium phosphate (TCP) were developed by taking into account mechanical properties of the bone to be replaced. FTIR spectra indicated the coating of TCP onto the polymer, providing hydrophilic surfaces necessary for cells to attach. As determined by DSC, the depression of PCL melting point suggested a uniform distribution of PCL within the TCP matrix. SEM micrographs revealed pores of irregular shapes varying from 100-200 µm in size in the resultant structures. Indeed, the pore morphology was precisely determined by the leached particles. The scaffolds could tolerate the impact of at least 5.6 kNm2, making them suitable for use as artificial bones of skull, clavicle and ribs. Rat bone stroma attached and survived on the scaffolds, indicating biocompatible of the used materials. Therefore, the prepared scaffolds would be applicable for bone tissue engineering in the near future.

  Info
Periodical
Advanced Materials Research (Volumes 93-94)
Edited by
S. Suttiruengwong and W. Sricharussin
Pages
67-70
DOI
10.4028/www.scientific.net/AMR.93-94.67
Citation
L. Kaewsichan, J. Kaewsrichan, T. Chuchom, "Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications", Advanced Materials Research, Vols. 93-94, pp. 67-70, 2010
Online since
January 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Yong Taek Hyun, Seung Eon Kim, S.J. Heo, Jung Woog Shin
Abstract:Porous and bioactive composite scaffolds based on poly ε-caprolactone(PCL) and hydroxyapatite(HA) were successfully fabricated by solvent...
109
Authors: C.L. Salgado, Zenaide Solomão, Priscilla B. Silva, Elisabete M.S. Sanchez, Cecília A.C. Zavaglia
Abstract:The Tissue Engineering appears with a modern proposal for the treatment of damages or diseases. The study of materials and methods for...
399
Authors: Xiu Feng Xiao, Jian Jin Jiao, Qiong Yu Huang, Rong Fang Liu
Biomaterials
Abstract:The polycaprolactone (PCL)/chitosan (CS) scaffolds were prepared by the freeze-solvent extraction method using glacial acetic acid with...
1695