Paper Title:
Product of Modified Rice Starch (Era-Gel®) and its Utilization in Pharmaceutical Industry
  Abstract

Pregelatinized rice starch (Era-Gel ® ) was prepared by physical modification. The degree of pregelatinization was controlled to an appropriate level. With the addition of small amount of pregelatinized rice starch , a slightly sticky, damped mass was obtained. Pregelatinized rice starch was tested for a potential use as a tablet filler or binder in wet granulation process. Two hydrochlorothiazide formulations were compared. One formulation comprised HCTZ and PRS; the powder mixture was damped with water. The other formulation contained HCTZ, lactose as filter, corn starch as binder and also as tablet disintegrant. In the later case, the powder mixture was damped with starch paste. Both granulations were compressed on an instrumented tablet press. The tablets were evaluated for their hardness, friability, disintegration, and also dissolution. The results indicated that both formulations were comparable in all aspects. It dissolution was found to exceed the USP requirement. It was demonstrated that three components, i.e. , lactose, corn starch paste, and disintegrant could be replaced with only one single material, PRS. It was also found that PRS could perform well in acetaminophen tablet formulation which was a high-dose drug and tended to cap; however, small amount of extra binder and disintegrant were needed. It could be seen that PRS had a great potential use in wet granulation process.

  Info
Periodical
Advanced Materials Research (Volumes 93-94)
Edited by
S. Suttiruengwong and W. Sricharussin
Pages
675-678
DOI
10.4028/www.scientific.net/AMR.93-94.675
Citation
V. Vongsurakrai, S. Varavinit, "Product of Modified Rice Starch (Era-Gel®) and its Utilization in Pharmaceutical Industry", Advanced Materials Research, Vols. 93-94, pp. 675-678, 2010
Online since
January 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Varatus Vongsurakrai, Saiyavit Varavinit
Abstract:Spray dried rice starch (SDRS ) (Era-Tab ®)was prepared by spray drying of rice starch at a suitable condition. Scanning electron microscope...
672
Authors: Varatus Vongsurakrai, Saiyavit Varavinit
Abstract:Starch-colloidal silicon dioxide mixtures (Era-Tab SP® ) was prepared by co-spray drying and dry mixing methods and the flow ability and...
679
Authors: Wipada Samprasit, Praneet Opanasopit, Prasert Akkaramongkolporn, Tanasait Ngawhirunpat, Kaewnapa Wongsermsin, Suwannee Panomsuk
Abstract:The purpose of this research was to mask the bitter taste of dextromethorphan hydrobromide using a cationic ion exchange resin,...
1384
Authors: Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu
Chapter 2: Mechanical Engineering
Abstract:In this paper, the mechanical properties of extended drug release systems were studied. A binder is a material that is added to a formulation...
143
Authors: Vipaluk Patomchaiviwat, Suchada Piriyaprasarth, Bunyarit Chaisomboonphan, Chitatharinth Limpoemwuttiporn, Pornsuda Nuamnoi
Chapter 1: Formulation, Manufacture and Fabrication, Characterization and Evaluation of Materials and Dosage Forms
Abstract:The aim of this study was to investigate the modification of black glutinous rice starch (BGRS) as tablet filler. The black glutinous rice...
58