In this study, numerical calculations of fatigue-creep interaction behavior for powder metallurgy materials with inclusion was carried out based on the Kachanov-Rabotnov damage law. The emphasis was placed on the influence of different fatigue cycle times and shape of inclusion on matrix damage for a constant of creep time. The results show that the creep damage law can be used to study the fatigue-creep interaction behavior of PM materials. And the creep damage increases with the fatigue cycle times increasing. The shape of inclusion remarkably influences the damage of matrix. Generally, elliptical inclusion causes much more damage to the matrix than the round inclusion.