Micro-thermoelectric generator device (MTGD) is used to supply lasting electrical energy for Micro-electro-mechanical systems (MEMS). As an important part of MTGD, micro-combustor with high energy density has direct influence on the total electrical generating efficiency for MTG. D In this paper, Considering some parameters such as material, dimension, flux of fuel and shape of thermal conductive tunnel for micro-combustor, some simulation models such as thermal transfer, combustion for micro-combustor were built up, and some simulation results were got. Based upon, optimized micro flat combustors were designed and tested. The experiment results illustrated that the conduct efficiency of micro-combustor was well controlled by adjusting heat flux, and the combustor with shape of zigzag combustion tunnel has high thermal exchange efficiency in experiment models. By adjusting flux of fuel and the structure of micro premixed combustor, the heat loss of MTGD was reduced and output power was improved in a degree.