When machining aerospace monolithic components, a severe deformation can be observed due to the release and redistribution of the original residual stresses, together with the action of cutting loads and clamping force. In this paper, a finite element model predicting machining deformation was developed considering the above mentioned multi-factors coupling effects. Based on the model, the effect of process routing on machining deformation for multi-frame double sided monolithic components was studied. To validate the FE model, true frame components were machined and deformations were measured on a Coordinate Measuring Machine. The result revealed that the prediction model is credible. At last the paper puts forwards optimal process routing based on minimizing the machining deformation.