The method for establishing the forming limit diagram (FLD) of multi-gauge high strength steel laser tailor-welded blanks (LTWB) is introduced based on analyzing the failure mechanism of multi-gauge LTWB. The Nakazima test is performed to generate the limit strain of multi-gauge high strength steel LTWB. By means of the ARGUS strain measuring system, the limit strain is measured and the FLD of LTWB is plotted subsequently. The FLD established by the Nakazima test is introduced into the FEA forming process as the failure criteria. Compared with the predicted result of the FLD of thinner metal, better correlation between the simulation and experimental results is indicated by adopting the FLD of LTWB as the necking criteria, which also reveals the validity and practicability of the FLD research method for multi-gauge high strength steel LTWB.