A low cycle fatigue life (LCF) prediction model for nickel-based single crystal (SC) is presented based on the LCF experiments of notched specimens. Fatigue notch factor is adopted to reflect the influence of notch shape on LCF. Orientation function is adopted to modify total strain range and eliminate the influence of orientation on LCF. Cycle stress ratio is adopted to reflect the influence of mean stress and cycle character on LCF. The predicted results shows that all the data are in the factor of 2.1 scatter band, which means that the model proposed in this work is reasonable.