The high strain rate compressive properties of UHMWPE/ vinyl ester 3D orthogonal woven composites are investigated experimentally. The composites are made from UHMWPE fiber 3D orthogonal woven preforms impregnated with vinyl ester resin by resin transfer molding. The samples are subjected to dynamic loading through the thickness direction using the Split Hopkinson Pressure Bar at three kinds of strain rate. The testing results are compared with the results of quasi-static tests on specimens with the same fiber volume fraction. The stress-strain relationships of UHMWPE/vinyl ester 3D orthogonal woven composites are rate dependent. It is found that the yield stress, strain at yield stress and modulus increased with the increased the strain rates. Additionally, the predominant failure mode of the composites under dynamic loading shear fracture from the optical microscopic images of fracture surfaces.