Paper Title:
Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications
  Abstract

The development of novel biodegradable scaffolds for the treatment of bone and cartilage defects is the subject of intense research. A successful scaffold will guide cell-attachment, proliferation and tissue regeneration. The objective of this study is to use freeform fabrication (robocasting) for the preparation of porous hybrid organic/inorganic materials with a well controlled architecture and porosity. Polymer/hydroxyapatite (HA) pastes with ceramic contents ranging between 0 to 70 wt. % are prepared by mixing ceramic powders with a solution of the polymer in methylene chloride. Two different polymers are studied: polylactide (PLA) and polycaprolactone (PCL). During the compression tests, the scaffolds show an elasto-plastic behavior with large plastic yielding and do not fail in a brittle manner. The mechanical response is anisotropic and depends significantly on the ceramic content and the type of polymer.

  Info
Periodical
Edited by
P. VINCENZINI and R. GIARDINO
Pages
153-158
DOI
10.4028/www.scientific.net/AST.49.153
Citation
J. Russias, E. Saiz, S. Deville, A. P. Tomsia, "Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications", Advances in Science and Technology, Vol. 49, pp. 153-158, 2006
Online since
October 2006
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$32.00
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