Paper Title:
Drug Release from Hydroxyapatite Implants with Different Microstructure and Phase Composition
  Abstract

The goal of our studies has been to determine under in vitro conditions the amount and rate of pentoxifylline release from the samples of modified hydroxyapatite [HAp-Ca10(PO4)6(OH)2] implants in the form of microporous blocks (heterogeneous system) as well as from hydroxyapatitegypsum pellets (homogeneous system). For the preparation of microporous hydroxapatite ceramics additives of calcium metaphosphate Ca(PO3)2 (5 and 10 wt. %) or hydrated magnesium orthophosphate Mg3(PO4)2·8H2O (10 wt. %) were used as modifiers. In the case of drug release from heterogeneous carriers, cylinders filled with 50 mg of PTX were used. In the homogeneous system the pellets made of HAp and CaSO4·1/2H2O powders with homogeneously incorporated of 50 mg PTX were applied. It has been shown that the process of drug release from multifunctional ceramic implants depends to a significant degree on the microstructure of the materials, and the type of carrier system (heterogeneous or homogeneous).

  Info
Periodical
Edited by
P. VINCENZINI and R. GIARDINO
Pages
62-67
DOI
10.4028/www.scientific.net/AST.49.62
Citation
A. Zima, B. Mycek, A. Ślósarczyk, J. Szymura-Oleksiak, Z. Paszkiewicz, "Drug Release from Hydroxyapatite Implants with Different Microstructure and Phase Composition", Advances in Science and Technology, Vol. 49, pp. 62-67, 2006
Online since
October 2006
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