Self-Organized Metal Oxide Exhibiting Enhanced Bioactivity |
| Journal |
Advances in Science and Technology (Volume 53) |
| Volume |
Biomedical Applications of Nano Technologies |
| Edited by |
P. VINCENZINI and R. BARBUCCI |
| Pages |
17-21 |
| DOI |
10.4028/www.scientific.net/AST.53.17 |
| Online since |
October, 2006 |
| Authors |
Robert L. Karlinsey,
Anderson T. Hara,
Clif W. Duhn
|
| Keywords |
Apatite, Blood, Niobium Oxide, Nucleation, Saliva |
| Abstract |
Self-assembled niobium oxide microcones produced by potentiostatic anodization with varied
NaF content (between 100 and 250 mg) in an HF electrolyte are shown to nucleate mineral when
immersed in supersaturated solutions emulating mineral content in saliva and blood. The most
extensive mineral coverage in 100 mL of 2.5 wt. % HF electrolyte occurs when NaF content is
about 100 mg with substantial mineral formation occurring within 24 hours. Higher salt content
apparently alters the conditions favoring mineral nucleation by generating smaller nucleation
centers that ultimately diminish the extent of mineral coverage. Additionally, nucleation kinetics
and morphological contrasts between mineral formed from saliva and blood is briefly discussed in
terms of the relative degree of supersaturation with respect to hydroxyapatite. Finally, we show that
the integrity of the microcone shape is not critical for mineral nucleation, an observation that builds
on our prior hypothesis by promoting the importance of self-assembly and crystal formation. Based
on these results, we demonstrate the influence of NaF and stress the role of the self-organization
process in producing effective mineral nucleation sites. |
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