Nanotechnology-Based Cell Sheet Engineering for Regenerative Medicine |
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| Journal | Advances in Science and Technology (Volume 53) |
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| Volume | Biomedical Applications of Nano Technologies |
| Edited by | P. VINCENZINI and R. BARBUCCI |
| Pages | 74-78 |
| DOI | 10.4028/www.scientific.net/AST.53.74 |
| Citation | Masayuki Yamato et al., 2006, Advances in Science and Technology, 53, 74 |
| Online since | October, 2006 |
| Authors | Masayuki Yamato, Teruo Okano |
| Keywords | Temperature-Responsive Surface, Tissue Engineering |
| Abstract | In order to realize true regenerative medicine, we have developed a novel technology for the reconstruction of tissues and organs by utilizing intelligent materials including temperature-responsive polymers. We developed temperature-responsive culture surfaces, on which temperature-responsive polymers are covalently immobilized. Cells are cultured on the surfaces at 37°C, and harvested as transplantable cell sheets by reducing temperature to 20°C. With these cell sheets we regenerate various kinds of tissues such as cornea and heart. |
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