Neurite Development in PC12 Cells on Nanostructured Substrates |
| Journal |
Advances in Science and Technology (Volume 53) |
| Volume |
Biomedical Applications of Nano Technologies |
| Edited by |
P. VINCENZINI and R. BARBUCCI |
| Pages |
85-90 |
| DOI |
10.4028/www.scientific.net/AST.53.85 |
| Online since |
October, 2006 |
| Authors |
Gui Gen Zhang,
Furqan Haq,
Anandan Venkatramani
|
| Keywords |
Nanopillars, Nanopore, Neurite Outgrowth, PC12 Cells, Substrate |
| Abstract |
We investigated the role of substrate topography on neurite development in
pheochromocytoma (PC12 cells) by culturing the cells on substrates having nanoscale pillars and
pores. In general, cells on nanopillars and nanopores developed fewer and shorter neurites as
compared to cells on smooth substrates. But in comparison between the nanopillars the nanopores,
cells on nanopores developed more and longer neurites than cells on nanopillars. These results
showed that PC12 cells were spatially aware of the difference in the nanoscale structures of the
underlying substrates and responded with differences in neurite outgrowth. This fact suggests the
possibility to use nanoscale topographic features to control neurite development in neurons. |
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