Paper Title:
Neurite Development in PC12 Cells on Nanostructured Substrates
  Abstract

We investigated the role of substrate topography on neurite development in pheochromocytoma (PC12 cells) by culturing the cells on substrates having nanoscale pillars and pores. In general, cells on nanopillars and nanopores developed fewer and shorter neurites as compared to cells on smooth substrates. But in comparison between the nanopillars the nanopores, cells on nanopores developed more and longer neurites than cells on nanopillars. These results showed that PC12 cells were spatially aware of the difference in the nanoscale structures of the underlying substrates and responded with differences in neurite outgrowth. This fact suggests the possibility to use nanoscale topographic features to control neurite development in neurons.

  Info
Periodical
Edited by
P. VINCENZINI and R. BARBUCCI
Pages
85-90
DOI
10.4028/www.scientific.net/AST.53.85
Citation
G. G. Zhang, F. Haq, A. Venkatramani, "Neurite Development in PC12 Cells on Nanostructured Substrates", Advances in Science and Technology, Vol. 53, pp. 85-90, 2006
Online since
October 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Yun Cang Li, Jian Yu Xiong, C.S. Wong, Peter D. Hodgson, Cui E Wen
Abstract: In the present study, titanium (Ti) samples were surface-modified by titania (TiO2), silica (SiO2) and hydroxyapatite (HA) coatings using a...
67
Authors: Hong Gi Oh, Hyo Geun Nam, Kwang Hwan Jhee, Joon Mook Lim, Kwang Soup Song
Chapter 5: Materials in Environmental and Biomedical Engineering
Abstract:We investigate the effect of cell culture conditions, using pristine graphene sheets as growth substrate, on the human nerve cell line...
311