Paper Title:
Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents
  Abstract

Injected, nano-scale drug delivery systems, or nanovectors, are ideal candidates to provide breakthrough solutions to the time-honored problem of optimizing therapeutic index for a treatment. Even modest amounts of progress towards this goal have historically engendered substantial benefits across multiple fields of medicine, with the translability, for example, from oncology to infectious diseases being granted by the fact that the progresses had a single common denominator in the underlying technological platform. In this work we combine multiscale molecular modeling and experimental approaches to define the mode and the molecular requirements of the interaction of oligonucleotide-based therapeutics (e.g., small interfering (si)RNA) and dendrimeric delivery reagents. In details, by mimicking in silico the experiments performed in vitro, information at the molecular level (e.g., interaction forces, mechanisms, structures, free energies of binding, self-assembly, etc.), which cannot be accessed by other experimental techniques, are obtained. Thus, critical molecular parameters for optimizing and de novo designing nanocargos for tissues and tumor specific uptake can be determined. This would provide valuable information to devise optimal delivery modalities that would increase the efficacy of siRNA therapeutics in cells and laboratory animals and move them toward clinical applications.

  Info
Periodical
Edited by
Pietro VINCENZINI and Danilo DE ROSSI
Pages
154-159
DOI
10.4028/www.scientific.net/AST.57.154
Citation
P. Posocco, G. M. Pavan, G. Scocchi, J. W. Handgraaf, A. Malek, M. Maly, M. Fermeglia, J. G.E.M. Fraaije, C. V. Catapano, A. Danani, S. Pricl, "Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents", Advances in Science and Technology, Vol. 57, pp. 154-159, 2008
Online since
September 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Arihiro Kano, Takeshi Yamano, Sun Won Choi, Atsushi Maruyama
Abstract:Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability...
762
Authors: Fang Gao
Chapter 9: Materials and Technology of Production
Abstract:Polyphosphate is a biocompatible, modified and functionalized biodegradable polymer. It has a broad application prospects in the field of...
605
Authors: Li Hui Zhao, He Nan Zhao, De Ming Han
Chapter 1: Nanomaterials and Applied Nanotechnologies
Abstract:This paper used double step compounding chitosan nanoparticles as carrier, took the virus's outer membrane NS1 shRNA delivery to cells,and...
43