In the last years there was an increasing interest of the scientific and technological community in the field of healthy and ecological buildings. Nanotechnology gives a substantial contribution in the development of new advanced materials, environmentally sustainable and safe for the consumers. Due to their multi-functional behaviour, nano-materials are at the basis of a revolutionary technical improvement in buildings: titania nano-structured films are applied on ceramic and glass surfaces increasing drastically the self-cleaning and anti bacterial activity. Substrates with controlled porosity can be designed to obtain anti-pollution surfaces either for external and internal environments, a photo reactor has been developed in our laboratory: a device to assess the photo degradation kinetic of pollutants (NOx and VOC’s) and help customers in the certification of eco-buildings. Surfaces based on nano-silver have been also developed leading to an anti bacterial effect in absence of light meanwhile anti-scratch and zero porosity substrates can be obtained from nano-zirconia and nano-silica suspensions. CERICOL has developed and scaled-up a “green chemistry” synthesis in water or glycols allowing simple industrial applications on different substrates as tiles, glass, plastic, paint, wood and concrete.