Paper Title:
Supramolecular Surfaces Modulating Cellular Response
  Abstract

Polyrotaxane-immobilized surfaces were prepared as a platform of dynamic surfaces, which can prevent from non-specific interaction with plasma proteins and platelet, and then modulate cellular functions via specific interaction with receptor protein-ligand binding through movable polyrotaxane backbone. The immobilization of the polyrotaxane was carried out via two-step protocol, in which the polyrotaxane with tetraethyleneglycol dodecanethiol (TEGDT) anchoring group at both terminals was fixed onto Au substrate via Au-S bond, followed by the fixation of TEGDT molecule onto the Au substrate to complete the loop formation of polyrotaxane on the Au substrate with the help of self-assembled monolayer formation of TEGDT. Their surface properties were characterized by means dynamic contact angle measurements, and preliminary studies as biomaterials were performed in terms of plasma protein adsorption onto their surfaces.

  Info
Periodical
Edited by
Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER
Pages
10-15
DOI
10.4028/www.scientific.net/AST.76.10
Citation
N. Yui, "Supramolecular Surfaces Modulating Cellular Response", Advances in Science and Technology, Vol. 76, pp. 10-15, 2010
Online since
October 2010
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$32.00
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