Paper Title:
Tissue Engineering with Natural Tissue Matrices
  Abstract

Natural tissue, especially autologous tissue is one of ideal materials for tissue regeneration. Decellularized tissue could be assumed as a second choice because the structure and the mechanical properties are well maintained. Decellularized human tissues, for instance, heart valve, blood vessel, and corium, have already been developed and applied clinically. Nowadays, decellularized porcine tissues are also investigated. These decellularized tissues were prepared by detergent treatment. The detergent washing is easy but sometime it has problems. We have developed the novel decellularization method, which applied the high-hydrostatic pressure (HHP). As the tissue set in the pressurizing chamber is treated uniformly, the effect of the high-hydrostatic pressurization does not depend on the size of tissue. We have reported the HHP decellularization of heart valve, blood vessel, bone, and cornea. Furthermore, HHP treatments are reported to have the ability of the extinction of bacillus and the inactivation of virus. So, the HHP treatment is also expected as the sterilization method. We are investigating efficient processes of decellularization and recellularization of biological tissues to have bioscaffolds keeping intact structure and biomechanical properties. Our recent studies on tissue engineering using HHP decellularized tissue will be reported here.

  Info
Periodical
Edited by
Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER
Pages
125-132
DOI
10.4028/www.scientific.net/AST.76.125
Citation
A. Kishida, S. Funamoto, J. Negishi, Y. Hashimoto, K. Nam, T. Kimura, T. Fujisato, H. Kobayashi, "Tissue Engineering with Natural Tissue Matrices", Advances in Science and Technology, Vol. 76, pp. 125-132, 2010
Online since
October 2010
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Price
$32.00
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