Paper Title:
A Hydroxyapatite-Collagen Composite Useful to Make Bioresorbable Scaffolds for Bone Reconstruction
  Abstract

Composites between hydroxyapatite (HA) and collagen (Col) may be used to make bioresorbable scaffolds for bone reconstruction. A suspension of micro-particles (average diameter ≅ 30 µm) of HA annealed at 1100°C in Col solution (80:20 HA to Col weight ratio) was manufactured in films by casting, and then some films were cross-linked by glutaraldehyde vapours. Cross-linked sponges were obtained by treating the suspension with transglutaminase, and by lyophilizing the so obtained gel. Characterization by scanning electron microscopy, water sorption test, Col release in water, thermogravimetric analysis and differential scanning calorimetry shows that the cross-linking enhances the stability of the composite. Conversely, neither the interactions between HA and Col, detected by spotlight FT-IR, nor the degradation by collagenase, which is a requirement for the bioresorbibility, are affected by the cross-linking.

  Info
Periodical
Edited by
Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER
Pages
133-138
DOI
10.4028/www.scientific.net/AST.76.133
Citation
G. D. Guerra, C. Cristallini, E. Rosellini, N. Barbani, "A Hydroxyapatite-Collagen Composite Useful to Make Bioresorbable Scaffolds for Bone Reconstruction", Advances in Science and Technology, Vol. 76, pp. 133-138, 2010
Online since
October 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: H.D. Cao, Yan Fei Tan, Xiao Yan Lin, Hong Song Fan, Xing Dong Zhang
Abstract:Glutaraldehyde was increasingly used to improve the stability of the collagen-based biomaterials as cross-linking. To investigate in vitro...
223
Authors: Kunjalukkal Padmanabhan Sanosh, Francesca Gervaso, Alessandro Sannino, Antonio Licciulli
VII. Scaffolds & Tissue Engineering
Abstract:In the present work Collagen/Hydroxyapatite microsphere (Col/mHA) scaffold with a multiscale porosity was prepared. Col/mHA composite...
239