The glass molding process (GMP) is regarded as a very promising technique for mass producing high precision optical components such as spherical/ aspheric glass lenses and free-form optics. However, only a handful of materials can sustain the chemical reaction, mechanical stress and temperature involved in the glass molding process. Besides, almost all of these mold materials are classified as hard-to-machine materials. This makes the machining of these materials to sub-micrometer form accuracy and nanometer surface finish a rather tough and expensive task. As a result, making mold life longer has become extremely critical in the GMP industry. The interfacial chemical reaction between optical glass and mold is normally the main reason for pre-matured mold failure. This research aimed to investigate the interfacial chemical reaction between various optical glasses, different anti-stick coating designs and several mold materials. The results showed that glass composition, coating design (composition, microstructure, thickness), environment (vacuum, air or in protective gas), reaction temperature and time could all have profound effects on the interfacial chemical reaction. Based on the results, a design developed specially for certain glasses is more likely to be the viable way of optimizing the effect of the protective coating.