Single vapour bubble growth and heat transfer mechanism during flow boiling in a rectangular horizontal mini-channel were experimentally investigated. The hydraulic diameter of the channel was 1454 μm, with an aspect ratio (Win/din) of 10. Degassed FC-72 was used as the working liquid. In this paper, bubble equivalent radius was found to increase linearly till a critical time, beyond which the growth turned into exponential. Bubble growth rate increases with increasing heat flux. Heat transfer mechanisms of the bubble growth at different heat fluxes and mass fluxes were discussed. In addition, the relation between thermal and flow conditions with bubble temporal geometry was explored.