Effect of Biomimetic Nanocrystalline Apatite Surface on Bone Ingrowth
|Periodical||Journal of Biomimetics, Biomaterials, and Tissue Engineering (Volume 12)|
|Main Theme||Journal of Biomimetics, Biomaterials & Tissue Engineering Vol.12|
|Citation||Jonathan Gelber et al., 2012, Journal of Biomimetics, Biomaterials, and Tissue Engineering, 12, 41|
|Online since||February, 2012|
|Authors||Jonathan Gelber, Juan C. Hermida, Shantanu Patil, Clifford W. Colwell, Darryl D. D'Lima|
|Keywords||Apatite, Biomimetic, Bone Growth, Hydroxyapatite (HAP), Nanocrystalline, Osseointegration (OI)|
The Success of Hydroxyapatite-Coated Acetabular Components Has Not Been Consistent. Plasma-Sprayed Hydroxyapatite Coatings Work Well on Nonporous Substrates but Do Not Coat the Inner Surfaces of Open-Porous Substrates. Solution Deposition Can Generate Consistent Bioceramic Coats on Porous Surfaces that More Closely Mimic the Trabecular Pattern and Biochemistry at the Bone Interface. we Compared Bone Response to the Following Implants: Porous-Coated Ti6al4v Cylinders with 1 of 3 Treatments: Plasma Sprayed with Hydroxyapatite (HA), Coated with a Solution-Deposited Biomimetic Apatite Coating (BA), and Untreated (Control). Bilateral Femurs in 36 Rabbits Were Implanted with One of the above Implants. Bone Ingrowth for HA and BA Surfaces Was Significantly Higher than that for Control Surfaces. No Fragmentation or Debris Production Was Evident in the Apatite Coat of the BA Group. A Biomimetic Coat of Solution-Deposited Apatite May Be Resistant to Coating Delamination and Particle Generation.