Paper Title:
Comparison of Electrospun PBSU and PLGA Scaffolds Applied in Vascular Tissue Engineering
  Abstract

Poly(butylenes succinate) (PBSU) had good biocompatibility and biodegradability, but it is left unexplored for the possible application of PBSU in tissue engineering. The aim of this study was to compare PBSU and poly (lactide-co-glycolide) (PLGA) scaffolds prepared by electrospinning technique as vascular tissue engineering materials. Both scaffolds were characterized by fiber morphology, pore structure and mechanical properties. Smooth muscle cells (SMCs) and endothelial cells (ECs) were seeded on the electrospun PBSU and PLGA scaffolds and cultured for different time periods. Cell adhesion and proliferation on the scaffolds were measured by MTT assay, while SEM was used for observing cell morphology on the scaffolds. The results showed that fiber diameter of the electrospun scaffolds ranged from 300nm to 800nm and their porosities were higher than 90%. The electrospun PBSU scaffolds showed a high tensile strength of 2.06±0.11MPa, whereas the ultimate tensile strength of the electrospun PLGA scaffolds reached 14.31±5.24MPa. Cell adhesion efficacy had no significant difference between PBSU and PLGA scaffolds, but cell proliferation rate on PLGA scaffolds was significantly higher than that on PBSU scaffolds after 7 days of culture. Cell morphology was similar on both scaffolds with the polygonal shape for ECs and spindle-like shape for SMCs. From these results, the present in vitro study revealed that as compared to PLGA scaffolds, the electrospun PBSU scaffolds showed lower tensile strength and slower proliferation rate, but as regards the biocompatibility and pore structure, the electrospun PBSU scaffolds had a potential application in vascular tissue engineering.

  Info
Pages
27-38
DOI
10.4028/www.scientific.net/JBBTE.2.27
Citation
L. Zhao, C. He, D. M. Zhang, J. Chang, L. Cui, "Comparison of Electrospun PBSU and PLGA Scaffolds Applied in Vascular Tissue Engineering", Journal of Biomimetics, Biomaterials and Tissue Engineering, Vol. 2, pp. 27-38, 2009
Online since
May 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Hyeong In Kim, Ji Yeon Seo, Seung Jo Jeung, Sae Gwang Park, Young Il Yang
Abstract:Fibrin is a natural substrate for growth, adhesion, and migration of mature endothelial cells (ECs) and a candidate coating material in...
17
Authors: Jiao Sun, Xin Ning Mu, Ting Ting Ding
Abstract:Materials used to make artificial vessels and hearts can cause thrombosis, thus hindering the development of these therapeutic aids....
1335
Authors: Bao Lin Xing, Chuan Xiang Zhang, Lun Jian Chen, Guang Xu Huang
Abstract:Activated carbons (ACs) were prepared from lignite by microwave (MW) and electrical furnace (EF) heating with KOH as activation agent. In...
2472
Authors: Ming Yan, Ke Di Xu, Xiao Xiang Zheng, Zheng Jian Chen, Hong Liang Jiang
Chapter 2: Material Science and Engineering
Abstract:An extracellular matrix-like poly (ε-caprolactone) (PCL)/gelatin core-shell nanofibrous scaffold with high hydrophilicity was developed by...
900
Authors: Xiao Li Liu, Ting Fei Xi, Yu Dong Zheng, Shao Kang Guan
Chapter 11: Bioresearch and Environmental Materials
Abstract:To evaluate biocompatibility of Mg-Zn-Y-Nd alloy as vascular stent material, its influence on cytotoxicity, cell migration, cell chemotaxis...
962