Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating

Miao, X.; Liu, J.; Dong, Z.

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Paper Titles

Porous PLGA Microspheres Effectively Loaded with BSA Protein by Electrospraying Combined with Phase Separation in Liquid Nitrogen, p.1
A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds, p.19
The Influence of Copolymer Compositions on the Physiochemical and Biological Properties of Poly (Lactic-co-Glycolic Acid) Porous Scaffolds, p.35
Designing Fail-Safe Biomaterials against Wear for Artificial Total Hip Replacement, p.45
The Application of Rapid Prototyping and Manufacturing for Anatomical Modelling in Medicine, p.57
Degradable Hydrogels for Tissue Engineering – Part I: Synthesis by RAFT Polymerization and Characterization of PHEMA Containing Enzymatically Degradable Crosslinks, p.67
Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating, p.87

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Paper Title:

Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating

Periodical	Journal of Biomimetics, Biomaterials, and Tissue Engineering (Volume 6)
Main Theme	Journal of Biomimetics, Biomaterials and Tissue Engineering Vol.6
Pages	87-104
DOI	10.4028/www.scientific.net/JBBTE.6.87
Citation	J. Liu et al., 2010, Journal of Biomimetics, Biomaterials, and Tissue Engineering, 6, 87
Online since	September, 2010
Authors	J. Liu, Z. Dong, X. Miao
Keywords	Bioactive Glass, Dip-Coating, Porosity, Strength, Vacuum Infiltration (VI), Zirconia-Toughened Alumina (ZTA)
Price	US$ 28,-

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Abstract

Strong and tough, macroporous alumina/zirconia composites are superior to alumina scaffolds but still biologically inert to bone tissue, leading to poor tissue ingrowth and osteointegration. One way to solve this problem is applying a bioactive coating onto the pore walls of the macroporous composites. In this study, macroporous alumina/zirconia (20vol%) composites (scaffolds) were prepared by a vacuum infiltration method involving the use of strained (10%) compacts of the expanded polystyrene (EPS) beads (typically 1-2.8 mm in diameter). A bioactive glass (58S33C) coating (~ 20 μm) was applied on the pore walls of the macroporous composites by slurry dip coating and sintering at 1200 oC for 1 hour. A top or outer bioactive glass (58S33C) thin layer (< 10 μm) was further applied by sol dip coating and sintering at a low temperature (< 800 °C). The bioactive glass-coated macroporous alumina/zirconia composites had well interconnected pores, relatively large pore sizes (1-2 mm), medium porosities (60-66%), high compressive strengths (7.52 – 5.42 MPa), and high bioactivity (with an apatite layer formed within 24 hours in the simulated body fluid). The combination of the strong and ultrafine (if not nano-structured) macroporous scaffolds with the multiple or graded bioactive coatings represented a new generation of bone substitutes or permanent scaffolds for bone tissue regeneration.