Paper Title:
Genetic Effects of Trabecular Titanium™ on Human Osteoblast-Like Cells (MG-63): An In Vitro Study
  Abstract

Pure titanium and titanium alloys are materials widely used in orthopaedics and dental surgery because of their mechanical properties, chemical stability and biocompatibility. Although excellent clinical results have been shown, traditional porous metals have several inherent limitations (low volumetric porosity, relatively high modulus of elasticity and low frictional characteristics, availability as a coating only). With the aim of moving beyond these limits, improving the potentiality of osteointegration and consequently the stability of prosthetic implants, a new highly porous titanium biomaterial (Trabecular Titanium™, TT) has been developed. In this in vitro study, we are testing the effects of TT on osteoblast-like cells (MG63) cultured on disks of this biomaterial by using DNA microarrays containing 20,000 genes. We identified several genes covering a broad range of functional activities whose expression was significantly up- or down-regulated. Findings from this study can give a detailed description of the genetic effects TT has on human osteoblast-like cells in vitro. We demonstrated that TT stimulates osteoblast proliferation and differentiation, and reduces osteoblast apoptosis. Moreover, TT limits osteoclastogenesis, inflammation and reduces the immunologic events against the material, modulating genes related to the immune system. Therefore, all these effects contribute to improve osseointegration and consequently survival of the prosthetic implants. These reported data encourage the clinical application of Trabecular Titanium™ to prosthetic devices.

  Info
Pages
1-16
DOI
10.4028/www.scientific.net/JBBTE.9.1
Citation
V. Sollazzo, F. Pezzetti, A. Palmieri, A. Girardi, F. Farinella, F. Carinci, "Genetic Effects of Trabecular Titanium™ on Human Osteoblast-Like Cells (MG-63): An In Vitro Study", Journal of Biomimetics, Biomaterials and Tissue Engineering, Vol. 9, pp. 1-16, 2011
Online since
January 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Hong Xin Wang, Zheng Xiang Xue, Mei Hong Wei, Deng Long Chen, Min Li
Abstract:As a new biomaterial, recombinant spider silk protein has attracted much attention in tissue engineering. The pNSR-16/ BL21(DE3)pLysS strains...
1734
Authors: Yuan Hua Zhang
Chapter 8: Biological Chemical and Technology
Abstract:By means of pharmacological approach and stomatal analysis,the role of G protein in light-regulated stomatal movement in Vicia faba L. was...
1196
Authors: Ting Wen, An Chun Cheng, Ming Shu Wang
Chapter 3: Biochemical, Medicine Engineering and Technologies, Applications of Genetic Engineering
Abstract:Previous studies indicate that the UL17 protein and its homology play similar roles in viral DNA cleavage and packaging of herpesviruses....
638
Authors: Xu Pan, An Chun Cheng, Ming Shu Wang, De Kang Zhu, Xiao Jia Wang
Chapter 2: Advanced Bio and Medical Engineering, Applications of Bioinformatics and Genetic Engineering
Abstract:The OmpA/MotB gene from RA by our lab was sequenced. And the molecular characteristic of this gene was analyzed with bioinformatics software....
304
Authors: Qian Da Cao, An Chun Cheng, Ming Shu Wang
Chapter 2: Advanced Bio and Medical Engineering, Applications of Bioinformatics and Genetic Engineering
Abstract:Great loss has been caused by Duck viral Hepatitis on waterfowl industry within the scope of world. But the information about the causative...
396