Paper Title:
A High-Resolution Amperometric Acetylcholine Sensor Based on Nano-Assembled Carbon Nanotube and Acetylcholinesterase Thin Films
  Abstract

We demonstrate a carbon nanotube based high-resolution biosensor for acetylcholine sensing. Carbon nanotubes are deposited on a silicon wafer in a repeated fashion with layer-by-layer nano self-assembly technique. With nano-assembled acetylcholinesterase molecules on the surface, the carbon nanotube biosensor is capable of detecting acetylcholine at an ultra-low concentration of 100 pM. The sensitivity of the acetylcholine sensor is measured as 7.2 µA/decade. The real-time measurement shows the response time of the biosensor is approximately 6 sec. Both the carbon nanotube film and the acetylcholinesterase film are crucial in the sensing process. Due to its high resolution, fast response, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications in medical research and clinical diagnosis.

  Info
Periodical
Edited by
Guest Editor: N. Ali
Pages
1-9
DOI
10.4028/www.scientific.net/JNanoR.1.1
Citation
W. Xue, T. H. Cui, "A High-Resolution Amperometric Acetylcholine Sensor Based on Nano-Assembled Carbon Nanotube and Acetylcholinesterase Thin Films", Journal of Nano Research, Vol. 1, pp. 1-9, 2008
Online since
January 2008
Export
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jing Jing Tian, Yuan Hong Xie, Xiang Ning Chen, Xi Yue, Zhen Long Guo, Wen Tao Xu
Chapter 8: Biomaterials, Biotechnology and Biochemistry
Abstract:Cholinesterase serves as a key enzyme of the cholinergic system, which could be one kind of promising biomaterial to assay OP and CB...
847
Authors: Rini Grace, Keerthana Sundar, N. Mohan, D. Selvakumar, N.S. Kumar
Abstract:A facile and sensitive enzyme based electrochemical transducer has been fabricated for the detection of organophosporus compounds. The...
67