Paper Title:
Porous Hollow Gold Nanoparticles for Cancer SERS Imaging

Surface enhanced Raman spectroscopy (SERS) is a promising molecular imaging modality capable of simultaneously detecting multiple molecular biomarkers. With the biocompatibility and functionalizability of Au, Au-nanoparticle based Raman tags possess the potential for in vivo SERS cancer biomarker detection. Here, we report the large scale synthesis of a new type of Au nanoparticles, Porous Hollow Au Nanoparticles (PHAuNPs), and demonstrate their potential application as SERS imaging tags. PHAuNPs feature a sub-20 nm porous shell and a 50 nm void core. Such unique morphology enables them to strongly absorb and scatter near infrared lights due to the surface plasmon resonant effect of Au. This makes them particularly suitable for in vivo applications, where NIR wavelengths are considered as a ‘clear window’ for deeper penetration of light. The construction and characterization of PHAuNP-based Raman nanotag, including attachment of Raman dye, pegylation and their stability, are described. Cytotoxicity of Raman nanotags are tested using the radioactive [3H]thymidine incorporation method. The results show that pegylated Raman nanotags are stable and non-toxic and can potentially be used for in vivo applications.

C. W. Huang, Y. W. Hao, J. Nyagilo, D. P. Dave, L. F. Xu, X. K. Sun, "Porous Hollow Gold Nanoparticles for Cancer SERS Imaging", Journal of Nano Research, Vol. 10, pp. 137-148, Apr. 2010
Online since
April 2010
US$ 28,-
Authors: Gil Pyo Kim, Seung Bum Yoon, Young Soo Jung, Jae Hoon Ahn, Sung Hyeon Baeck, Alan Kleiman-Schwarsctein, Eric W. Mc Farland
Abstract:Nanoparticles (Au, Pt, Ru) supported on metal oxides (TiO2, Heteropoly Acid) were prepared by PS-PVP block copolymer encapsulation method....
Authors: Chien Jung Huang, Pin Hsiang Chiu, Yeong Her Wang
Abstract:This paper describes a sol-gel (SG) method for the coating of gold nanoparticles with uniform shells of amorphous silica. The thickness of...
Authors: V.L. Gayou, B. Salazar Hernández, R. Delgado Macuil, G. Zavala, P. Santiago, A.I. Oliva
Abstract:Zinc sulfide (ZnS), a representative of wide band gap semiconductor nanocrystals, has an excitonic Bohr radius (aBZnS ) of 2.5 nm. It makes...
Authors: Vladimir A. Vinokurov, Alexander V. Muradov, Michael Getmanskiy, Le Qiu, Edward Vitkin, Irving Itzkan, Lev T. Perelman
Chapter 2: Medical Diagnostics and Imaging
Abstract:In this paper we discuss the potential of nonspherical gold nanoparticles to serve as extremely bright light scattering labels for the...
Authors: Jun Tang, Huan Fei Wen, Peng Lan Chai, Jun Liu, Yun Bo Shi, Chen Yang Xue
Abstract:In this work, an interesting phenomenon demonstrating the similarities between the results from both Surface Enhanced Raman Spectroscopy...