Paper Title:
Preparation of Porous Biphasic Calcium Phosphate-Gelatin Nanocomposite for Bone Tissue Engineering
  Abstract

A new porous structure as a bone tissue engineering scaffold was developed by a freeze-drying method. The porous nanocomposite was prepared from Biphasic Calcium Phosphate (BCP) which was a mixture of 70% hydroxy apatite and 30%ß-TCP (ß-Tricalcium Phosphate). Porogen was naphthalene and gelatin from bovine skin type B was used as polymer. Gelatin was stabilized with EDC (N-(3-dimethyl aminopropyl)-N´-ethyl carbodiimide hydrochloride) by a cross-linking method. The scaffold was characterized by scanning electronic microscope (SEM), Fourier-Transformed Infrared spectroscopy (FTIR). The biocompatibility of this nanocomposite carried out through MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a tetrazole) cell viability assay. Also other properties of scaffold such as morphology, grain size, bending strength were investigated. Highly porous structure with interconnected porosities, good mechanical behavior and high biocompatibility with bone tissue, were benefits of this porous nanocomposite for bone tissue engineering.

  Info
Periodical
Edited by
Guest Editors: Andreas Öchsner, Irina V. Belova and Graeme E. Murch
Pages
67-72
DOI
10.4028/www.scientific.net/JNanoR.11.67
Citation
L. Bakhtiari, H. R. Rezaie, S.M. Hosseinalipour, M. A. Shokrgozar, "Preparation of Porous Biphasic Calcium Phosphate-Gelatin Nanocomposite for Bone Tissue Engineering", Journal of Nano Research, Vol. 11, pp. 67-72, 2010
Online since
May 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: D.J. Yang, Timur R. Tadjiev, Jae Woong Kim, Chang Kuk You, S.K. Choi, K.B. Park, K.H. Ryoo, Suk Young Kim
Abstract:Surface morphology and degradation behavior of mechanically mixed and chemically precipitated biphasic calcium phosphate (M-BCP and P-BCP)...
227
Authors: Sandra Sánchez-Salcedo, Daniel Arcos, Maria Vallet-Regí
Abstract:The research on ceramic scaffolds for bone tissue engineering is, nowadays, one of the newest and most attractive topics in the field of...
19
Authors: Ho Yeon Song, Young Hee Kim, Jyoti M. Anirban, In Seon Byun, Kyung A Kwak, Byong Taek Lee
Abstract:Calcium phosphate ceramics such as hydroxy apatite (HA), β-tricalcium phosphate (β-TCP) and bicalcium phosphate (BCP) have been used as a...
2065
Authors: Min Sung Kim, Dong Woo Jang, Young Ki Min, Hun Mo Yang, Ho Yeon Song, Byong Taek Lee
Abstract:Calcium phosphate bone substitutes are widely used for providing support for the in-growth of hard tissue in various medical applications...
2245
Authors: M. Ebrahimi, Naruporn Monmaturapoj, S. Suttapreyasri, P. Pripatnanont
II. Biomaterials Science
Abstract:The biphasic calcium phosphate (BCP) concept was introduced to overcome disadvantages of single phase biomaterials. In this study, we...
57