Synthesize and Characterization of Multifunctional Silica Coated Magnetic Nanoparticles Using Polyvinylpyrrolidone (PVP) as a Mediator

Magnetic iron oxide nanoparticles with proper surface coatings are increasingly being evaluated for clinical applications such as hyperthermia, drug delivery, magnetic resonance imaging, transfection and cell/protein separations. In this work, silica coated iron oxide magnetic nanoparticles, which are very useful for delivering chemotherapeutic drugs, has been prepared by precipitation in an aqueous solution of iron (II) and iron (III) chlorides under basic condition. In this process, polyvinylpyrrolidone (PVP) has been used as a stablizer. Surface modifications of the as-prepared Fe3O4 Nps have been carried out by using tetraethoxysilane (TEOS). Silica coated nanoparticles have been characterized by Fourier transform infrared (FTIR) spectroscopy, Powder X- ray diffraction (XRD), Transmission electron microscopy (TEM) and Infrared (IR) spectroscopy