In the past decades, porous materials have attracted great scientific and industrial interest due to their appealing structures and potential applications in separation, purification, catalysis, devices, and so forth. The developing community of ordered mesoporous materials has carried on this exploration of the mesoscopical territory, which promises their unique capacities related to large molecules and their transportation in confined space. Thus rational control and adjustment of pores have been continually focused during the synthesis of ordered mesoporous materials with diverse intrinsic properties. In this work, vitamin C encapsulated mesoporous silica was successfully synthesized with tetraethylorthosilicate (TEOS). TEOS was subjected to sol-gel process in the presence of cetyltrimethylammonium bromide (CTAB). The composition and size of mesoporous silica was controlled by fitting the molar ratio of starting materials. The mesoporous silica can be applied to the field of the cosmetics and bio-medicine as drug delivery.