Titanium alloy matrix composites (TMCs) have received considerable interest as structural materials for aeronautical applications, because of their higher specific strength and stiffness. When applying TMCs at elevated temperatures, high temperature isothermal low-cycle fatigue (LCF)failure is one of critical issues to be concerned. A unidirectionally reinforced SCS-6/ SP-700 composite is a tentative target in this work, where the matrix alloy, SP-700 is a new generation high strength Titanium alloy developed by NKK Inc., and the SCS-6 is a beta-SiC fiber developed by Textron Specially Materials, respectively. A merit to employ the SP-700 is that this alloy enables to reduce a fabrication temperature, because of its capability for superplasticity at relatively lower temperatures. The 7-plies composite specimen was produced by hot isostatic pressing (HIP) at 800°C for 0.5 hrs. in vacuum, alternating layers of thin-foils of the SP-700 and the green tapes of the SCS-6 fibers, so that the fibers were uniformly distributed as a hexagonal array in the matrix. The volume fraction of the fibers in the composite is about 28 %. In this work, the following articles in a unidirectionally reinforced SCS-6/SP-700 composite have been studied and evaluated: (i)mechanical properties of the SCS-6/SP-700 composite and the matrix alloy at temperatures ranged between room temperature and 450°C; (ii) LCF lives and the failure modes of the composite and the matrix alloy at room temperature and 450°C; (iii) fiber push-out tests at elevated temperatures ranged between room temperature and 600°C, to represent the fiber/matrix interfacial strength; and (iv) observation and the characterization of the interfacial reaction zone by means of a transmission electron microscope (TEM) and an energy dispersive X-ray spectrometer (EDS). Based on these experimental results, the effects of temperature and the loading frequency on LCF failure of the SCS-6/SP-700 composite were discussed.