In this study, we investigated the reliability assessment of exhaust manifold used in thermomechanical condition. Overlay model proposed by Besseling was modified to consider the strain range dependence on elastic limit. By combining geometrical relation in hysteresis loop and temperature dependence of elastic limit with isothermal overlay model, temperature dependent cyclic plasticity model was proposed. Continuous damage model based on isothermal fatigue data was generalized for non-isothermal condition. Finite element analysis and life prediction of exhaust manifold were performed under severe operating conditions.