In order to develop a corrosion fatigue design method and estimate reliability of TMCP steel using as the material of heavy industries and plants, its electrochemical corrosion characteristics and determination of corrosion fatigue design criterion were investigated. And, a corrosion fatigue design method of TMCP steel was also investigated. From the results, the corrosion characteristic of TMCP steel is very susceptible in 3.5wt.% NaCl solution. Its susceptibility was linearly increased with the solution temperature increase. Corrosion fatigue strength in 25°C, 3.5wt.% NaCl solution is very lower than that of in air. And also, it was decreased with loading frequency decrease in the same environment. It was found that corrosion fatigue strength and life of TMCP steel is predictable by using the S-N curve of fatigue strength in air. Therefore, it is expected that the developed corrosion fatigue design method for TMCP steel will be useful for safe design and reliability assessment of the industrial facilities and structures.