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Biocompatibility of Phema and P(Hema-Co-Sma) Hydrogels

Journal Key Engineering Materials (Volumes 277 - 279)
Volume On the Convergence of Bio-, Information-, Enrivonmental-, Energy-, Space- and Nano-Technolgies
Edited by Kwang Hwa Chung, Yong Hyeon Shin, Sue-Nie Park, Hyun Sook Cho, Soon-Ae Yoo, Byung Joo Min, Hyo-Suk Lim and Kyung Hwa Yoo
Pages 51-55
DOI 10.4028/www.scientific.net/KEM.277-279.51
Online since January, 2005
Authors Bo Hyung Park, Young A Han, Jin Hyun Choi, Jeong Ok Lim
Keywords Biocompatibility, Biomaterial, Cell Adhesion, Cytotoxicity, Implantation, In Vivo Tissue Reaction, Mechanically Strong Hydrogel, P(HEMA-Co-SMA), pHEMA
Abstract To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.
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