Paper Title:
Controlled Release of Vancomycin from Poly(Dl-Lactide-Co-Glycolide) Disc: Inhibition of Mrsa(Methicillin Resistant Staphylococcus Aureus) Growth in Vitro
  Abstract

A different range of vancomycin was incorporated into a poly dl-lactide-co-glycolide) [PLGA] disc matrix using the hot compression method. The disc was placed in phosphate buffered saline (PBS) and incubated at 37oC. The PBS was changed periodically, and the removed solution was analyzed using high performance liquid chromatography. The sensitivity of the antibiotic-polymer matrix was evaluated using cultured-human-ear methicillin-resistant staphylococcus aureus (MRSA). The MRSA growth was inhibited proportionally to the incorporated vancomycin concentration in the disc matrix. A disc incorporating 400 µg of antibiotics inhibited the growth of MRSA 10 times longer than the disc containing 30 µg as a control. It was found that the biodegradable polymer matrix enabled the control-release of an antibiotic, and the release profile was observed as zero order.

  Info
Periodical
Key Engineering Materials (Volumes 277-279)
Edited by
Kwang Hwa Chung, Yong Hyeon Shin, Sue-Nie Park, Hyun Sook Cho, Soon-Ae Yoo, Byung Joo Min, Hyo-Suk Lim and Kyung Hwa Yoo
Pages
72-76
DOI
10.4028/www.scientific.net/KEM.277-279.72
Citation
J. O. Lim, W. K. Lee, I. S. Park, J. S. Hwang, J. M. Suh, W. Y. Baek, S. H. Lee, "Controlled Release of Vancomycin from Poly(Dl-Lactide-Co-Glycolide) Disc: Inhibition of Mrsa(Methicillin Resistant Staphylococcus Aureus) Growth in Vitro", Key Engineering Materials, Vols. 277-279, pp. 72-76, 2005
Online since
January 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Celso A. Bertran, S. Bertazzo, L.L. Almeida, A.V. Souza Jr.
Abstract:The surface of alumina discs (γ phase) was modified by the reaction between the Al-OH groups on the surface of alumina and oxalic acid,...
753
Authors: Liang Yu, Yan Li Jiang, Sen Kai Lu, Hong Qiang Ru, Ming Fang
Chapter 1: Computer-Aided Design, Manufacturing and Engineering
Abstract:The shaft disc prepared with SiC 3D continuous ceramic frame reinforced aluminum alloy 7075 (3D-SiC/Al) composite of the CRH3 high speed...
51
Authors: Zbigniew Respondek, Zbigniew Rajczyk, Mariusz Kosiń, Damian Jończyk, Jarosław Kalinowski
Chapter 2: Mechanical Engineering and Manufacture Applications
Abstract:Concrete surfaces are becoming increasingly popular in road construction around the world. This is due to a number of advantages, such as...
97
Authors: Saad A. Alsubaie, Yi Huang, Terence G. Langdon
Chapter 2: Contributed Papers
Abstract:Experiments were conducted on an AZ80 magnesium alloy by processing by high-pressure torsion (HPT) at room temperature (296 K) for up to 10...
139